Quantifying brain tumor tissue abundance in HR‐MAS spectra using non‐negative blind source separation techniques
Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014Quantifying brain tumor tissue abundance in HR‐MAS spectra using non‐negative blind source separation techniques
Auteurs : Anca Ramona Croitor Sava [Belgique] ; M. Carmen Martinez-Bisbal [Espagne] ; Diana Maria Sima [Belgique] ; Jorge Calvar [Argentine] ; Vicente Esteve [Espagne] ; Bernardo Celda [Espagne] ; Uwe Himmelreich [Belgique] ; Sabine Van Huffel [Belgique]Source :
- Journal of Chemometrics [ 0886-9383 ] ; 2012-07.
Abstract
Given high‐resolution magic angle spinning (HR‐MAS) spectra from several glial tumor subjects, our goal is to differentiate between tumor tissue types by separating the different sources that contribute to the profile of each spectrum. Blind source separation techniques are applied for obtaining characteristic profiles for necrosis, highly cellular tumor and border tumor tissue and providing the contribution (abundance) of each of these tumor tissue types to the profile of each spectrum. The problem is formulated as a non‐negative source separation problem. Non‐negative matrix factorization, convex analysis of non‐negative sources and non‐negative independent component analysis methods are considered. The results are in agreement with the pathology obtained by the histopathological examination that succeeded the HR‐MAS measurements. Furthermore, an analysis to verify to which extent the dimension of the input space, the input features and the number of sources to be extracted from the HR‐MAS data could influence the performance of the source separation is presented. Copyright © 2012 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/cem.2456
Affiliations:
- Argentine, Belgique, Espagne
- Province du Brabant flamand, Région flamande
- Louvain
- Katholieke Universiteit Leuven
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantifying brain tumor tissue abundance in HR‐MAS spectra using non‐negative blind source separation techniques</title><author><name sortKey="Croitor Sava, Anca Ramona" sort="Croitor Sava, Anca Ramona" uniqKey="Croitor Sava A" first="Anca Ramona" last="Croitor Sava">Anca Ramona Croitor Sava</name></author><author><name sortKey="Martinez Isbal, M Carmen" sort="Martinez Isbal, M Carmen" uniqKey="Martinez Isbal M" first="M. Carmen" last="Martinez-Bisbal">M. Carmen Martinez-Bisbal</name></author><author><name sortKey="Sima, Diana Maria" sort="Sima, Diana Maria" uniqKey="Sima D" first="Diana Maria" last="Sima">Diana Maria Sima</name></author><author><name sortKey="Calvar, Jorge" sort="Calvar, Jorge" uniqKey="Calvar J" first="Jorge" last="Calvar">Jorge Calvar</name></author><author><name sortKey="Esteve, Vicente" sort="Esteve, Vicente" uniqKey="Esteve V" first="Vicente" last="Esteve">Vicente Esteve</name></author><author><name sortKey="Celda, Bernardo" sort="Celda, Bernardo" uniqKey="Celda B" first="Bernardo" last="Celda">Bernardo Celda</name></author><author><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name></author><author><name sortKey="Van Huffel, Sabine" sort="Van Huffel, Sabine" uniqKey="Van Huffel S" first="Sabine" last="Van Huffel">Sabine Van Huffel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B6099F881F0EE4E01987813A48E88BFA2F3AABDD</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1002/cem.2456</idno><idno type="url">https://api.istex.fr/document/B6099F881F0EE4E01987813A48E88BFA2F3AABDD/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000964</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="ISTEX">000964</idno><idno type="wicri:Area/Main/Curation">000964</idno><idno type="wicri:Area/Main/Exploration">000013</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Quantifying brain tumor tissue abundance in HR‐MAS spectra using non‐negative blind source separation techniques</title><author><name sortKey="Croitor Sava, Anca Ramona" sort="Croitor Sava, Anca Ramona" uniqKey="Croitor Sava A" first="Anca Ramona" last="Croitor Sava">Anca Ramona Croitor Sava</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Electrical Engineering (ESAT) Division SCD, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>IBBT‐K.U.Leuven Future Health Department, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Belgique</country></affiliation></author><author><name sortKey="Martinez Isbal, M Carmen" sort="Martinez Isbal, M Carmen" uniqKey="Martinez Isbal M" first="M. Carmen" last="Martinez-Bisbal">M. Carmen Martinez-Bisbal</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Química‐Física, Facultad de Química, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER‐BBN, ISC‐III, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Sima, Diana Maria" sort="Sima, Diana Maria" uniqKey="Sima D" first="Diana Maria" last="Sima">Diana Maria Sima</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Electrical Engineering (ESAT) Division SCD, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>IBBT‐K.U.Leuven Future Health Department, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Calvar, Jorge" sort="Calvar, Jorge" uniqKey="Calvar J" first="Jorge" last="Calvar">Jorge Calvar</name><affiliation wicri:level="1"><country xml:lang="fr">Argentine</country><wicri:regionArea>FLENI, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Esteve, Vicente" sort="Esteve, Vicente" uniqKey="Esteve V" first="Vicente" last="Esteve">Vicente Esteve</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Química‐Física, Facultad de Química, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER‐BBN, ISC‐III, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Celda, Bernardo" sort="Celda, Bernardo" uniqKey="Celda B" first="Bernardo" last="Celda">Bernardo Celda</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Química‐Física, Facultad de Química, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER‐BBN, ISC‐III, Universitat de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Biomedical MRI Unit/Molecular Small Animal Imaging Center, Department of Imaging and Pathology, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation></author><author><name sortKey="Van Huffel, Sabine" sort="Van Huffel, Sabine" uniqKey="Van Huffel S" first="Sabine" last="Van Huffel">Sabine Van Huffel</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Electrical Engineering (ESAT) Division SCD, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><orgName type="university">Katholieke Universiteit Leuven</orgName><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>IBBT‐K.U.Leuven Future Health Department, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Chemometrics</title><title level="j" type="abbrev">J. Chemometrics</title><idno type="ISSN">0886-9383</idno><idno type="eISSN">1099-128X</idno><imprint><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2012-07">2012-07</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="406">406</biblScope><biblScope unit="page" to="415">415</biblScope></imprint><idno type="ISSN">0886-9383</idno></series><idno type="istex">B6099F881F0EE4E01987813A48E88BFA2F3AABDD</idno><idno type="DOI">10.1002/cem.2456</idno><idno type="ArticleID">CEM2456</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0886-9383</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Given high‐resolution magic angle spinning (HR‐MAS) spectra from several glial tumor subjects, our goal is to differentiate between tumor tissue types by separating the different sources that contribute to the profile of each spectrum. Blind source separation techniques are applied for obtaining characteristic profiles for necrosis, highly cellular tumor and border tumor tissue and providing the contribution (abundance) of each of these tumor tissue types to the profile of each spectrum. The problem is formulated as a non‐negative source separation problem. Non‐negative matrix factorization, convex analysis of non‐negative sources and non‐negative independent component analysis methods are considered. The results are in agreement with the pathology obtained by the histopathological examination that succeeded the HR‐MAS measurements. Furthermore, an analysis to verify to which extent the dimension of the input space, the input features and the number of sources to be extracted from the HR‐MAS data could influence the performance of the source separation is presented. Copyright © 2012 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Argentine</li><li>Belgique</li><li>Espagne</li></country><region><li>Province du Brabant flamand</li><li>Région flamande</li></region><settlement><li>Louvain</li></settlement><orgName><li>Katholieke Universiteit Leuven</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Croitor Sava, Anca Ramona" sort="Croitor Sava, Anca Ramona" uniqKey="Croitor Sava A" first="Anca Ramona" last="Croitor Sava">Anca Ramona Croitor Sava</name></region><name sortKey="Croitor Sava, Anca Ramona" sort="Croitor Sava, Anca Ramona" uniqKey="Croitor Sava A" first="Anca Ramona" last="Croitor Sava">Anca Ramona Croitor Sava</name><name sortKey="Croitor Sava, Anca Ramona" sort="Croitor Sava, Anca Ramona" uniqKey="Croitor Sava A" first="Anca Ramona" last="Croitor Sava">Anca Ramona Croitor Sava</name><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name><name sortKey="Sima, Diana Maria" sort="Sima, Diana Maria" uniqKey="Sima D" first="Diana Maria" last="Sima">Diana Maria Sima</name><name sortKey="Sima, Diana Maria" sort="Sima, Diana Maria" uniqKey="Sima D" first="Diana Maria" last="Sima">Diana Maria Sima</name><name sortKey="Van Huffel, Sabine" sort="Van Huffel, Sabine" uniqKey="Van Huffel S" first="Sabine" last="Van Huffel">Sabine Van Huffel</name><name sortKey="Van Huffel, Sabine" sort="Van Huffel, Sabine" uniqKey="Van Huffel S" first="Sabine" last="Van Huffel">Sabine Van Huffel</name></country><country name="Espagne"><noRegion><name sortKey="Martinez Isbal, M Carmen" sort="Martinez Isbal, M Carmen" uniqKey="Martinez Isbal M" first="M. Carmen" last="Martinez-Bisbal">M. Carmen Martinez-Bisbal</name></noRegion><name sortKey="Celda, Bernardo" sort="Celda, Bernardo" uniqKey="Celda B" first="Bernardo" last="Celda">Bernardo Celda</name><name sortKey="Celda, Bernardo" sort="Celda, Bernardo" uniqKey="Celda B" first="Bernardo" last="Celda">Bernardo Celda</name><name sortKey="Esteve, Vicente" sort="Esteve, Vicente" uniqKey="Esteve V" first="Vicente" last="Esteve">Vicente Esteve</name><name sortKey="Esteve, Vicente" sort="Esteve, Vicente" uniqKey="Esteve V" first="Vicente" last="Esteve">Vicente Esteve</name><name sortKey="Martinez Isbal, M Carmen" sort="Martinez Isbal, M Carmen" uniqKey="Martinez Isbal M" first="M. Carmen" last="Martinez-Bisbal">M. Carmen Martinez-Bisbal</name></country><country name="Argentine"><noRegion><name sortKey="Calvar, Jorge" sort="Calvar, Jorge" uniqKey="Calvar J" first="Jorge" last="Calvar">Jorge Calvar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/AussoisV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000013 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000013 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= AussoisV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B6099F881F0EE4E01987813A48E88BFA2F3AABDD
|texte= Quantifying brain tumor tissue abundance in HR‐MAS spectra using non‐negative blind source separation techniques
}}
| This area was generated with Dilib version V0.6.29. |  |